She is best known for hosting MTV's Total Request Live (TRL), 2003–2007 and as an Entertainment Tonight NYC correspondent, 2005-2007.

She hosted Miss Teen USA (2004) and co-hosted Miss Universe (2007).

Minnillo was a finalist in E!'s competition to find a replacement for Brooke Burke as host for the show Wild On[citation needed] losing out to Cindy Taylor.

Since leaving MTV and Entertainment Tonight, she has been featured in a print and web-based advertising campaign for BONGO Jeans' Spring/Summer 2007 collection

She has been the spokesperson of Flirt! Cosmetics, a line she helped create that debuted in August 2007 in Kohl's department stores.

In May 2006, Maxim magazine listed Minnillo as #15 in its Hot 100 issue.

She was on the Read more...

Minnillo was featured in Vegas magazine (2008) where she revealed her next path of career is acting. She later confirmed to People magazine she indeed got a role in the movie "Redefining Love" out (2009), she also started shooting her first spoof movie/comedy Disaster Movie out August 29, 2008.