After the Canadian wish-fulfillment TV series Thrill of a Lifetime arranged for her to pose for Hugh Hefner's Playboy, she gained fame as the Playmate of the Month for the November 1981 issue (photographed by Richard Fegley) and eventually the Playmate of the Year for 1982. Since then, Tweed has primarily acted in TV series such as the HBO comedy 1st and Ten, the prime-time soap opera Falcon Crest and guest appearances on Frasier, as well as B movies. Tweed also appeared in an episode of The Dukes of Hazzard in the seventh and final season. In 1985, she landed a role on Days of Our Lives as Savannah Wilder, a character who was working under Victor Kiriakis and through whom Steve "Patch" Johnson was introduced. She remained with the show until 1987.

Her first major theatrical film appearance was in the teen sex comedy Hot Dog... The Movie in 1984. Since then, Tweed has appeared in over 60 films, including Detroit Rock City, produced by Gene Simmons in 1999. She is one of the be