Alexander was a regular on two short-lived series, the medical drama Presidio Med and ABC's twenty-something drama Wasteland. She appeared on the fourth season of Dawson's Creek as Gretchen Witter, dating the title character, and in an episode of the short-lived Fox comedy series Greg the Bunny, playing the part of a lesbian TV Guide reporter and shared a memorable onscreen kiss with Sarah Silverman. Alexander has also appeared in the films Lucky 13, and All Over the Guy. Her role on NCIS ended in May 2005 and she had a small role in 2006's Mission Impossible III. She joined the cast of The Nine in the role of Nick's ex-wife. She also did one episode of Friends ("The One with Joey's Interview"), playing a Soap Opera Digest reporter who interviewed Joey.