Arquette was born in New York City, the daughter of Mardi Olivia (née Nowak), an actress, poet, theater operator, activist, acting teacher and therapist, and Lewis Arquette, an actor and director. Arquette's paternal grandfather was comedian Cliff Arquette. Arquette's mother was Jewish, the daughter of a Holocaust refugee from Poland, and her father was a convert to Islam and a descendant of Read more...

In Hollywood, she had her first roles playing teens with troubles. A few years later she started to act in mature roles. Besides films, Arquette appeared from the beginning of her career in television films. In 1982, she earned an Emmy Award nomination for the TV film The Executioner's Song. Thereafter, she played in many cinema movies and TV films and has worked with many of the most acclaimed Read more...

Arquette was married when she was 19 to director/composer Tony Greco; they divorced in October 1980. Arquette briefly dated Toto member Steve Porcaro; the band's Grammy Award-winning single "Rosanna", the lead track on the album Toto IV, was named after her, but the song itself was not about her, according to writer David Paich. In a 1983 interview with Rolling Stone, Arquette said that she used Read more...