Sofer's first high profile role was as Rocky on the daytime soap opera Loving, a role she played from 1988 to 1991. She is perhaps best known for her role as Lois Cerullo on General Hospital from 1994 to 1996. Her portrayal of the outrageous Lois won Sofer a Daytime Emmy Award in 1995 for "Outstanding Supporting Actress in a Drama Series."

Sofer has appeared in several high profile prime-time TV series in a guest star/supporting cast member roles: Melrose Place, The Chronicle, Ed, Friends, Blind Justice, 24, and Seinfeld.

Sofer was the subject of controversy in the early 2000s when she briefly joined the cast of the NBC sitcom Just Shoot Me!, playing the character Vicky Costa. It was widely reported that NBC executives forced Read more...

In film, she has appeared as an involuntary love interest of Ben Stiller in the film Keeping the Faith, starring Jenna Elfman, Stiller, and Edward Norton (who also directed).

She also appeared as a bride to-be in Melanie Griffith's movie A Stranger Among Us.

She also appreared in Penelope Buitenhius's movie The Secret of Hidden Lake.