Gilpin is one of the children of the late Jim O'Brien, a Baptist minister who became a musician and was later a well-known and respected radio and TV News weatherman/personality in Philadelphia until his death in a skydiving accident on September 25, 1983. Her siblings, Marc Gilpin and April Gilpin, are also actors. Peri was known as Peri Kay Oldham before becoming an actress. She was raised in Read more...

With Frasier co-star Jane Leeves, she runs the production company Bristol Cities. Their latest project was a pilot for a US remake of the British sitcom The Vicar of Dibley, with Kirstie Alley in the title role.

Gilpin is the voice actress for the character Jane Proudfoot in Final Fantasy: The Spirits Within. She also provides the voices of Desiree in the Nickelodeon animated television series, Read more...

She married Christian Vincent on July 31, 1999. The couple had twins born via a surrogate mother in 2004.

She was named after the squirrel "Perri" from a Disney True-Life Adventures documentary.