Harris was born and raised in London, England, the daughter of sitcom writer Lisselle Kayla, a single mother who had emigrated to England from Jamaica as a child. After graduating in 1998 from Pembroke College, Cambridge with an undergraduate degree in social and political science, Harris trained at the Bristol Old Vic Theatre School. Harris is a Buddhist.

From an interview with Daily Mail: Read more...

Harris has appeared in television and film since she was nine, including a stint on the remake of the science fiction series The Tomorrow People. She became internationally well-known in 2002 with her lead performance in Danny Boyle's post-apocalyptic film 28 Days Later, opposite Cillian Murphy. In the same year, she starred in the television adaptation of Zadie Smith's White Teeth.

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Naomie Melanie Harris (born 6 September 1976) is an English screen actress known for her starring role as Selena in 28 Days Later and her supporting turn as Tia Dalma in the second and third Pirates of the Caribbean movies.