Otto's first post-graduation film role in 1991, as Nell Tiscowitz in The Girl Who Came Late, was her breakthrough role, which brought her to the attention of the Australian film industry and the general public. In the film, directed by Kathy Mueller, she starred as a young woman who could communicate with horses. Her appearance garnered Otto her first Australian Film Institute nomination for "Best Read more...

Otto's first Hollywood role was opposite Harrison Ford and Michelle Pfeiffer in the suspense thriller What Lies Beneath in 2000. She played Mary Feur, a mysterious next-door neighbor. The film was met with mixed reviews, but was an international success, grossing US$291 million. In 2001, Otto was cast as a naturalist in the comedy Human Nature. Writer and director Spike Jonze, impressed by her audition Read more...

Otto made her theatrical debut in the 1986 production of The Bitter Tears of Petra Von Kant for the Sydney Theatre Company. Three more theatrical productions for the Sydney Theatre Company followed in the late 1980s and early 1990s. In 2002, she returned to the stage playing Nora Helmer in A Doll's House opposite her future husband Peter O'Brien. Otto's performance earned her a 2003 Helpmann Award Read more...