Rogers was born Miriam Spickler in Coral Gables, Florida, the daughter of Philip J. Spickler, a civil engineer. Rogers, whose father was Jewish and mother Episcopalian, became a member of the Church of Scientology. Her first husband, Jim Rogers, was also a Scientologist. They were married from 1977 until 1980. Her second husband was actor Tom Cruise; they were married from 1987 until 1990. She introduced Cruise to Scientology. She also led others besides Cruise to the church, including Sonny Bono and football player John Brodie, for whom she served as auditor. Later, she left Scientology.

In 2003, she married producer Chris Ciaffa; they have two children, Lucy (born 1995) and Charles (born 2001).