Her first major screen role was in 1980 in the films The Hollywood Knights and Falling in Love Again. However, both films failed to get her widespead notice. She tried a TV career when she starred in Great Yellow Bird, Fantasy Island, Callie & Son, Splendor in the Grass, "Scarface", and The Children Nobody Wanted. She returned to film in Grease 2; it was weakly received by critics and audiences, Read more...

Through the 1990s, she continued her Hollywood stardom: The Russia House, Frankie and Johnny starring Al Pacino, Batman Returns starring Michael Keaton & Danny Devito, The Age of Innocence, Wolf starring Jack Nicholson, Dangerous Minds (Pfeiffer also made a cameo in the music video for Coolio's Gangsta's Paradise, the signature tune from the film's soundtrack) , and One Fine Day starring George Read more...

In 2000, she starred with Harrison Ford in one of the biggest box office hits of the year, Robert Zemeckis's supernatural thriller What Lies Beneath. In 2001, she starred opposite Sean Penn in I Am Sam and in 2002 alongside Renée Zellweger and Robin Wright Penn in White Oleander, which earned her a Screen Actors Guild Award nomination as Best Supporting Actress.

She then took a lengthy Read more...