Michele appeared in music videos, some of which were by R&B crooner Freddie Jackson. Michele is known for her role as Dr. Cleo Finch on the television series ER from 1999-2002 and her role as Det. Rene Sheppard on the final season of Homicide: Life on the Street. She also had a starring role in the short-lived television series Kevin Hill and a recurring role in New York Undercover. Michele played the role of Veronica Porsche Ali in the 2001 film, Ali. She appeared in an episode of Law & Order: Special Victims Unit, that aired early 2007. She also appeared in two episodes in the fourth season of House as a doctor previously working with the CIA.