Griffin describes herself as a "militant atheist". While in high school, she fell away from the Roman Catholic Church and wanted to become a Unitarian. Said Griffin: "I'm not really sure what that is, but it sounds better."

She is an outspoken opponent of LASIK eye surgery, having endured a series of operations for her own eyesight that left her partially blind in one eye with a visible eyeball Read more...

Griffin married Washington, D.C. native Matt Moline on February 18, 2001 atop the 360 Degree Restaurant in Hollywood. ABC News reported that she walked down the aisle to the strains of the 1980s power ballad "Sister Christian" by Night Ranger. Her maid of honor was Brooke Shields, and the wedding was attended by, among others, Rebekah Kelley, Camryn Manheim, Bill Maher, James Williams, and Jane Read more...

Griffin began performing in the early 1980s Los Angeles improv comedy troupe, The Groundlings. In an E! True Hollywood Story segment, she stated that she often went to see shows at the Groundlings before she joined. She said one time she was there she went backstage and talked with a Groundling member (Phil Hartman) and asked him what The Groundlings were all about. This led to her taking classes Read more...