Gertz made her film debut (as did Tom Cruise) in the 1981 romance film Endless Love and then appeared in the teen movie Sixteen Candles in 1984. She gained attention with a starring role in 1987's Less Than Zero, as the friend of a doomed drug addict played by Robert Downey, Jr.. She also starred in the 80's film Lost Boys. She plays a vampire with co-star Keifer Sutherland.

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Gertz was born in Chicago, Illinois, the daughter of Sharon and Walter Gertz, who was a builder and contractor. She lives in Los Angeles with her husband Antony Ressler (6/16/59) and their three sons: Oliver, Nicholas, and Theo. She has a brother Scott. Gertz is Jewish, and was raised in Conservative Judaism.

Jami Beth Gertz (born October 28, 1965) is an American actress. Gertz is known for her early roles in the film The Lost Boys, Quicksilver, Less Than Zero, the short-lived 1980s TV series Square Pegs with Sarah Jessica Parker, as well as the 2000s CBS sitcom Still Standing with Mark Addy.