Keener, the third of five children, was born in Miami, Florida, the daughter of Evelyn and Jim Keener, a manager of an automotive store. She is of Irish descent on her father's side and of Lebanese descent on her mother's. Keener attended Immaculate Conception Catholic School in Hialeah, Florida. Although she didn’t get into trouble growing up, by the time she reached high school at Monsignor Read more...

Keener officially broke into films with one line in About Last Night (1986). Although she struggled professionally over the next few years one low-quality project had an unexpected dividend. Keener met her future husband, actor Dermot Mulroney in 1987 while working on Survival Quest (1989), after Mulroney became stuck while attempting to scale a cliff.

She also guest-starred as an artist on Read more...

Keener married actor Dermot Mulroney in 1990. The couple had a son Clyde Keener Mulroney (born June 21, 1999), before separating in September 2005. In June 2007, Mulroney filed for divorce, citing irreconcilable differences. The divorce became final on December 19, 2007; she is now dating Benicio Del Toro. Keener is a close friend of actors Brad Pitt and Jennifer Aniston, Pitt and Keener having Read more...