Not long after, Nolasco guest-starred in various television series such as Arli$$, CSI: Crime Scene Investigation and ER. His first role on a feature film was as "Orange Julius" in Universal's 2 Fast 2 Furious. He then went on to co-star opposite Bernie Mac in Mr. 3000.

Nolasco's additional television and film credits include guest-starring roles on George Lopez, CSI: NY and The Benchwarmers. He also appeared on Mind of Mencia as a guest on Sunday, April 29, 2007. His most high-profile role to date was in the smash-hit Transformers movie, released during the summer of 2007.

Nolasco also made a guest appearance in Will.I.Am's music video, "Yes We Can", which shows support for the 2008 presidencial candidate, Barack Obama.