Milano was born in New York City, the daughter of Italian-American parents Lin, a former fashion designer and talent manager, and Thomas M. Milano, a film music editor and a well-known boating enthusiast. She has a younger brother, Cory (born in 1982), who is also an actor, but has more recently started a band, called Chloroform Days, in which he is the lead singer. Milano was born in Brooklyn but Read more...

At the beginning of her career, Milano was known mainly for her role on Who's the Boss? (1984-1992). She tried to shed her "nice girl" image by appearing in several films targeted at adults, such as Casualties of Love: The Long Island Lolita Story (1992), Embrace of the Vampire (1994), Confessions of a Sorority Girl (1994), Deadly Sins (1995), and Poison Ivy II: Lily (1995), where she starred opposite Read more...

Outside of acting, her hobbies include photography, humanitarian work and spending time with her three dogs and eight horses.

Milano suffers from dyslexia. In an interview in 2004, Milano explained how she deals with the disorder:

Milano is a fan of tattoos, and has eight of them located in various areas of her body, including both wrists, both ankles, shoulder, neck, hip and lower back. Read more...